A new model of Notch signalling: Control of Notch receptor cis-inhibition via Notch ligand dimers.

ABSTRACT: All tissue development and replenishment relies upon the breaking of symmetries leading to the morphological and operational differentiation of progenitor cells into more specialized cells. One of the main engines driving this process is the Notch signal transduction pathway, a ubiquitous signalling system found in the vast majority of metazoan cell types characterized to date. Broadly speaking, Notch receptor activity is governed by a balance between two processes: 1) intercellular Notch transactivation triggered via interactions between receptors and ligands expressed in neighbouring cells; 2) intracellular cis inhibition caused by ligands binding to receptors within the same cell. Additionally, recent reports have also unveiled evidence of cis activation. Whilst context-dependent Notch

SUBMITTER: Chen D 

PROVIDER: S-EPMC9891537 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature