Testing the ion-current model for flagellar length sensing and IFT regulation.

ABSTRACT: Eukaryotic cilia and flagella are microtubule-based organelles whose relatively simple shape makes them ideal for investigating the fundamental question of organelle size regulation. Most of the flagellar materials are transported from the cell body via an active transport process called intraflagellar transport (IFT). The rate of IFT entry into flagella, known as IFT injection, has been shown to negatively correlate with flagellar length. However, it remains unknown how the cell measures the length of its flagella and controls IFT injection. One of the most-discussed theoretical models for length sensing to control IFT is the ion-current model, which posits that there is a uniform distribution of Ca²⁺ channels along the flagellum and that the Ca²⁺ current from the fl

SUBMITTER: Ishikawa H 

PROVIDER: S-EPMC9891718 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature