Detrimental impact of aqueous mobile phases on 18F-labelled radiopharmaceutical analysis via radio-TLC.

ABSTRACT: The list of new positron-emission tomography (PET) tracers has rapidly grown in the past decade, following discoveries of new biological targets and therapeutic strategies, with several compounds garnering recent regulatory approval for clinical use. During the development of synthesis methods and production of new tracers for imaging, analytical methods for radio-high performance liquid chromatography (radio-HPLC) and radio-thin layer chromatography (radio-TLC) separations need to be developed to assess radiochemical compositions. Radio-TLC is often faster, simpler, and sometimes more accurate than radio-HPLC (as there is no underestimation of [¹⁸F]fluoride when analyzing ¹⁸F-labeled radiopharmaceuticals). Many protocols have been developed for separating ¹⁸

SUBMITTER: Laferriere-Holloway TS 

PROVIDER: S-EPMC9891729 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature