Effects of medwakh smoking on salivary metabolomics and its association with altered oral redox homeostasis among youth.

ABSTRACT: The use of alternative tobacco products, particularly medwakh, has expanded among youth in the Middle East and around the world. The present study is conducted to investigate the biochemical and pathophysiological changes caused by medwakh smoking, and to examine the salivary metabolomics profile of medwakh smokers. Saliva samples were collected from 30 non-smokers and 30 medwakh smokers and subjected to metabolomic analysis by UHPLC-ESI-QTOF-MS. The CRP and Glutathione Peroxidase 1 activity levels in the study samples were quantified by ELISA and the total antioxidant capacity (TAC) by TAC assay kits. Statistical measurements and thorough validation of data obtained from untargeted metabolomics identified 37 uniquely and differentially abundant metabolites in saliva of medwakh smokers. Th

SUBMITTER: Aghila Rani KG 

PROVIDER: S-EPMC9891755 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature