Microbiota composition in the lower respiratory tract is associated with severity in patients with acute respiratory distress by influenza.

ABSTRACT: Several factors are associated with the severity of the respiratory disease caused by the influenza virus. Although viral factors are one of the most studied, in recent years the role of the microbiota and co-infections in severe and fatal outcomes has been recognized. However, most of the work has focused on the microbiota of the upper respiratory tract (URT), hindering potential insights from the lower respiratory tract (LRT) that may help to understand the role of the microbiota in Influenza disease. In this work, we characterized the microbiota of the LRT of patients with Influenza A using 16S rRNA sequencing. We tested if patients with different outcomes (deceased/recovered) and use of antibiotics differ in their microbial community composition. We found important differences in the d

SUBMITTER: Hernandez-Teran A 

PROVIDER: S-EPMC9891757 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature