Exploration of the Long Noncoding RNAs Involved in the Crosstalk between M2 Macrophages and Tumor Metabolism in Lung Cancer

ABSTRACT:

Background

Complex regulation exists between tumor metabolism and M2 macrophages. Long noncoding RNAs (lncRNAs) are famous for their wide regulatory role. This study aimed to identify the lncRNAs involved in the crosstalk between tumor metabolism and M2 macrophages.

Methods

The Cancer Genome Atlas was responsible for the public data. R software was responsible for the analysis of public data.

Results

Based on the input expression profile, we quantified the M2 macrophage infiltration using the CIBERSORT algorithm and found that M2 macrophages were a risk factor for lung cancer. Also, we found that M2 macrophages were correlated with multiple metabolism pathways. Then, 67 lncRNAs involved in both M2 macrophages and related metabolism pathways were identified. A

SUBMITTER: Fang F 

PROVIDER: S-EPMC9891836 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature