Grip strength is inversely associated with DNA methylation age acceleration.

ABSTRACT:

Background

There is a large body of evidence linking muscular weakness, as determined by low grip strength, to a host of negative ageing-related health outcomes. Given these links, grip strength has been labelled a 'biomarker of aging'; and yet, the pathways connecting grip strength to negative health consequences are unclear. The objective of this study was to determine whether grip strength was associated with measures of DNA methylation (DNAm) age acceleration.

Methods

Middle age and older adults from the 2006 to 2008 waves of the Health and Retirement Study with 8-10 years of follow-up were included. Cross-sectional and longitudinal regression modelling was performed to examine the association between normalized grip strength (NGS) and three measures of DNAm age accelera

SUBMITTER: Peterson MD 

PROVIDER: S-EPMC9891916 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature