Targeting the DP2 receptor alleviates muscle atrophy and diet-induced obesity in mice through oxidative myofiber transition.

ABSTRACT:

Background

Mammalian skeletal muscles consist of two main fibre types: slow-twitch (type I, oxidative) and fast-twitch (type IIa, fast oxidative; type IIb/IIx, fast glycolytic). Muscle fibre composition switch is closely associated with chronic diseases such as muscle atrophy, obesity, type II diabetes and athletic performance. Prostaglandin D₂ (PGD₂ ) is a bioactive lipid derived from arachidonic acid that aggravates muscle damage and wasting during muscle atrophy. This study aimed to investigate the precise mechanisms underlying PGD₂ -mediated muscle homeostasis and myogenesis.

Methods

Skeletal muscle-specific PGD₂ receptor DP2-deficient mice (DP2^fl/fl HSA^Cre ) and their littermate controls (DP2^fl/fl

SUBMITTER: Ning H 

PROVIDER: S-EPMC9891918 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature