Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis.

ABSTRACT:

Background

Sarcopenia, the age-related decline in skeletal muscle mass and function, diminishes life quality in elderly people. Improving the capacity of skeletal muscle differentiation is expected to counteract sarcopenia. However, the mechanisms underlying skeletal muscle differentiation are complex, and effective therapeutic targets are largely unknown.

Methods

The human Gene Expression Omnibus database, aged mice and primary skeletal muscle cells were used to assess the expression level of pyruvate dehydrogenase B (PDHB) in human and mouse aged state. d-Galactose (d-gal)-induced sarcopenia mouse model and two classic cell models (C2C12 and HSkMC) were used to assess the myogenic effect of PDHB and the underlying mechanisms via immunocytochemistry, western blotting, quant

SUBMITTER: Jiang X 

PROVIDER: S-EPMC9891931 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature