Trajectories of physical and mental functioning over 25 years before onset of frailty: results from the Whitehall II cohort study.

ABSTRACT:

Background

Research on frailty, a major contributor to heterogeneity in health, is undertaken on older adults although the processes leading to frailty are likely to begin earlier in the life course. Using repeat data spanning 25 years, we examined changes in physical and mental functioning before the onset of frailty, defined using Fried's frailty phenotype (FFP).

Methods

Functioning was measured using the Short-Form 36 General Health Survey (SF-36) on nine occasions from 1991 (age range 40-63 years) to 2015 (age range 63-85 years). The poorest of four FFP scores from 2002, 2007, 2012 and 2015 was used to classify participants as frail, pre-frail, or robust. We used linear mixed models with a backward timescale such that time 0 was the person-specific date of frailty classi

SUBMITTER: Landre B 

PROVIDER: S-EPMC9891967 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature