A ubiquitous endocrine disruptor tributyltin induces muscle wasting and retards muscle regeneration.

ABSTRACT:

Background

Organotin pollutant tributyltin (TBT) is an environmental endocrine disrupting chemical and is a known obesogen and diabetogen. TBT can be detected in human following consumption of contaminated seafood or water. The decrease in muscle strength and quality has been shown to be associated with type 2 diabetes in older adults. However, the adverse effects of TBT on the muscle mass and function still remain unclear. Here, we investigated the effects and molecule mechanisms of low-dose TBT on skeletal muscle regeneration and atrophy/wasting using the cultured skeletal muscle cell and adult mouse models.

Methods

The mouse myoblasts (C2C12) and differentiated myotubes were used to assess the in vitro effects of low-dose tributyltin (0.01-0.5 μM). The in vivo effects of

SUBMITTER: Chiu HC 

PROVIDER: S-EPMC9891973 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature