Analysis of the adiponectin paradox in healthy older people.

ABSTRACT:

Background

It remains unknown why adiponectin levels are associated with poor physical functioning, skeletal muscle mass and increased mortality in older populations.

Methods

In 190 healthy adults (59-86 years, BMI 17-37 kg/m² , 56.8% female), whole body skeletal muscle mass (normalized by height, SMI, kg/m² ), muscle and liver fat were determined by magnetic resonance imaging. Bone mineral content (BMC) and density (BMD) were assessed by dual X-ray absorptiometry (n = 135). Levels of insulin-like growth factor 1 (IGF-1), insulin, inflammation markers, leptin and fibroblast growth factor 21 were measured as potential determinants of the relationship between adiponectin and body composition.

Results

Higher adiponectin levels were associated with a

SUBMITTER: Walowski CO 

PROVIDER: S-EPMC9891976 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature