Clonal hematopoiesis in men living with HIV and association with subclinical atherosclerosis.

ABSTRACT:

Objectives

People with HIV (PWH) are at increased risk for premature cardiovascular disease (CVD). Clonal hematopoiesis is a common age-related condition that may be associated with increased CVD risk. The goal of this study was to determine the prevalence of clonal hematopoiesis and its association with chronic inflammation and CVD in PWH.

Design

Cross-sectional study utilizing archived specimens and data from 118 men (86 PWH and 32 HIV-uninfected) from the Baltimore-Washington DC center of the Multicenter AIDS Cohort Study (MACS) who had had coronary computed tomography angiography (CTA) and measurement of 34 serologic inflammatory biomarkers.

Methods

Clonal hematopoiesis was assessed on peripheral blood mononuclear cells utilizing targeted error-corrected next gene

SUBMITTER: Wang S 

PROVIDER: S-EPMC9891994 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature