Dendritic cells direct circadian anti-tumour immune responses.

ABSTRACT: The process of cancer immunosurveillance is a mechanism of tumour suppression that can protect the host from cancer development throughout its lifetime^1,2. However, it is unknown whether the effectiveness of cancer immunosurveillance fluctuates over a single day. Here we demonstrate that the initial time of day of tumour engraftment dictates the ensuing tumour size across mouse cancer models. Using immunodeficient mice as well as mice lacking lineage-specific circadian functions, we show that dendritic cells (DCs) and CD8⁺ T cells exert circadian anti-tumour functions that control melanoma volume. Specifically, we find that rhythmic trafficking of DCs to the tumour draining lymph node governs a circadian response of tumour-antigen-specific CD8⁺ T cells that

SUBMITTER: Wang C 

PROVIDER: S-EPMC9891997 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature