Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.

ABSTRACT: Diabetes represents a spectrum of disease in which metabolic dysfunction damages multiple organ systems including liver, kidneys and peripheral nerves^1,2. Although the onset and progression of these co-morbidities are linked with insulin resistance, hyperglycaemia and dyslipidaemia^3-7, aberrant non-essential amino acid (NEAA) metabolism also contributes to the pathogenesis of diabetes^8-10. Serine and glycine are closely related NEAAs whose levels are consistently reduced in patients with metabolic syndrome^10-14, but the mechanistic drivers and downstream consequences of this metabotype remain unclear. Low systemic serine and glycine are also emerging as a hallmark of macular and peripheral nerve disorders, correlating with impaired visual acuity

SUBMITTER: Handzlik MK 

PROVIDER: S-EPMC9891999 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature