Programming multicellular assembly with synthetic cell adhesion molecules.

ABSTRACT: Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell-cell interactions in processes as diverse as tissue development, immune cell trafficking and the wiring of the nervous system^1-4. Here we show that a wide array of synthetic cell adhesion molecules can be generated by combining orthogonal extracellular interactions with intracellular domains from native adhesion molecules, such as cadherins and integrins. The resulting molecules yield customized cell-cell interactions with adhesion properties that are similar to native interactions. The identity of the intracellular domain of the synthetic cell adhesion molecules specifies interface morphology and mechanics, whereas diverse homotypic or heterotypic extracellular interaction domains indepen

SUBMITTER: Stevens AJ 

PROVIDER: S-EPMC9892004 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature