Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis.

ABSTRACT: The signal modelling framework JimenaE simulates dynamically Boolean networks. In contrast to SQUAD, there is systematic and not just heuristic calculation of all system states. These specific features are not present in CellNetAnalyzer and BoolNet. JimenaE is an expert extension of Jimena, with new optimized code, network conversion into different formats, rapid convergence both for system state calculation as well as for all three network centralities. It allows higher accuracy in determining network states and allows to dissect networks and identification of network control type and amount for each protein with high accuracy. Biological examples demonstrate this: (i) High plasticity of mesenchymal stromal cells for differentiation into chondrocytes, osteoblasts and adipocytes and differ

SUBMITTER: Kaltdorf M 

PROVIDER: S-EPMC9892028 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature