Advanced glycation end-products, cardiac function and heart failure in the general population: The Rotterdam Study.

ABSTRACT:

Aims/hypothesis

The aim of this work was to assess the association of advanced glycation end-products (AGEs), measured by skin autofluorescence (SAF), with prevalent heart failure, and with systolic and diastolic cardiac function, in a large population-based cohort study.

Methods

We assessed the cross-sectional association between SAF and prevalent heart failure among 2426 participants from the population-based Rotterdam Study, using logistic regression. Next, among individuals free of heart failure (N=2362), we examined the link between SAF (on a continuous scale) and echocardiographic parameters of left ventricular (LV) systolic and diastolic function using linear regressions. Analyses were adjusted for traditional cardiovascular risk factors.

Results

Higher levels

SUBMITTER: Arshi B 

PROVIDER: S-EPMC9892093 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature