Transferrin-modified chitosan nanoparticles for targeted nose-to-brain delivery of proteins.

ABSTRACT: Nose-to-brain delivery presents a promising alternative route compared to classical blood-brain barrier passage, especially for the delivery of high molecular weight drugs. In general, macromolecules are rapidly degraded in physiological environment. Therefore, nanoparticulate systems can be used to protect biomolecules from premature degradation. Furthermore, targeting ligands on the surface of nanoparticles are able to improve bioavailability by enhancing cellular uptake due to specific binding and longer residence time. In this work, transferrin-decorated chitosan nanoparticles are used to evaluate the passage of a model protein through the nasal epithelial barrier in vitro. It was demonstrated that strain-promoted azide-alkyne cycloaddition reaction can be utilized to attach a function

SUBMITTER: Gabold B 

PROVIDER: S-EPMC9892103 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature