Kidney function measures and cardiovascular outcomes in people with diabetes: the Hoorn Diabetes Care System cohort.

ABSTRACT:

Aims/hypothesis

Both manifestations of kidney disease in diabetes, reduced eGFR (ml/min per 1.73 m²) and increased urinary albumin/creatinine ratio (UACR, mg/mmol), may increase the risk of specific CVD subtypes in adults with diabetes.

Methods

We assessed the prospective association between annually recorded measures of eGFR and UACR and the occurrence of myocardial infarction (MI), CHD, stroke, heart failure (HF) and cardiovascular mortality in 13,657 individuals with diabetes (53.6% male, age 62.3±12.1 years) from the Hoorn Diabetes Care System cohort, using data obtained between 1998 and 2018. Multivariate time-dependent Cox regression models adjusted for cardiovascular risk factors were used to estimate HRs and 95% CI. Associations of eGFR were adjusted for U

SUBMITTER: Dal Canto E 

PROVIDER: S-EPMC9892144 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature