Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy.

ABSTRACT:

Aims/hypothesis

No established blood-based biomarker exists to monitor diabetic sensorimotor polyneuropathy (DSPN) and evaluate treatment response. The neurofilament light chain (NFL), a blood biomarker of neuroaxonal damage in several neurodegenerative diseases, represents a potential biomarker for DSPN. We hypothesised that higher serum NFL levels are associated with prevalent DSPN and nerve dysfunction in individuals recently diagnosed with diabetes.

Methods

This cross-sectional study included 423 adults with type 1 and type 2 diabetes and known diabetes duration of less than 1 year from the prospective observational German Diabetes Study cohort. NFL was measured in serum samples of fasting participants in a multiplex approach using proximity extension assay technology. D

SUBMITTER: Maalmi H 

PROVIDER: S-EPMC9892145 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature