Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart.

ABSTRACT: We studied time course of pathological remodeling occurring in the cynomolgus monkey hearts against persistent atrioventricular block condition (n = 10). The atrioventricular block induced the ventricular and atrial dilation followed by the ventricular hypertrophy. Interstitial fibrosis in the ventricle was also observed along with gradual increases in the plasma angiotensin II and aldosterone concentrations. These adaptations were associated with the changes in gene expression profiling reflecting fibrosis and hypertrophy. Atrioventricular block reduced the ventricular rate and cardiac output, but the ejection fraction and stroke volume increased, whereas the cardiac output was gradually restored to its basal level. Systolic/diastolic blood pressure after the atrioventricular block

SUBMITTER: Izumi-Nakaseko H 

PROVIDER: S-EPMC9892184 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature