Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is a chronic, food-driven allergic disease, characterized by eosinophil-rich inflammation in the esophagus. The histopathological and clinical features of EoE have been attributed to overproduction of the type 2 cytokines IL-4 and IL-13, which mediate profound alterations in the esophageal epithelium and neutralizing of their shared receptor component (IL-4Rα) with a human antibody drug (dupilumab) demonstrates clinical efficacy. Yet, the relative contribution of IL-4 and IL-13 and whether the type II IL-4 receptor (comprised of the IL-4Rα chain in association with IL-13Rα1) mediates this effect has not been determined.

Methods

Experimental EoE was induced in WT, Il13ra1^-/- , and Krt14^Cre /Il13ra1^fl/fl

SUBMITTER: Avlas S 

PROVIDER: S-EPMC9892241 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature