Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN].

ABSTRACT:

Background

Turmeric is a commonly used herbal product that has been implicated in causing liver injury. The aim of this case series is to describe the clinical, histologic, and human leukocyte antigen (HLA) associations of turmeric-associated liver injury cases enrolled the in US Drug-Induced Liver Injury Network (DILIN).

Methods

All adjudicated cases enrolled in DILIN between 2004 and 2022 in which turmeric was an implicated product were reviewed. Causality was assessed using a 5-point expert opinion score. Available products were analyzed for the presence of turmeric using ultra-high-performance liquid chromatography. Genetic analyses included HLA sequencing.

Results

Ten cases of turmeric-associated liver injury were found, all enrolled since 2011, and 6 since 2017.

SUBMITTER: Halegoua-DeMarzio D 

PROVIDER: S-EPMC9892270 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature