Does gabapentin provide benefit for patients with knee OA? A benefit-harm and cost-effectiveness analysis.

ABSTRACT:

Objective

Gabapentin can treat neuropathic pain syndromes and has increasingly been prescribed to treat nociplastic pain. Some patients with knee osteoarthritis (OA) suffer from both nociceptive and nociplastic pain. We examined the cost-effectiveness of adding gabapentin to knee OA care.

Method

We used the Osteoarthritis Policy Model, a validated Monte Carlo simulation of knee OA, to examine the value of gabapentin in treating knee OA by comparing three strategies: 1) usual care, gabapentin sparing (UC-GS); 2) targeted gabapentin (TG), which provides gabapentin plus usual care for those who screen positive for nociplastic pain on the modified PainDETECT questionnaire (mPD-Q) and usual care only for those who screen negative; and 3) universal gabapentin plus usual care (UG).

SUBMITTER: Bensen GP 

PROVIDER: S-EPMC9892279 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature