Systematic Review and Meta-analysis: Task-based fMRI Studies in Youths With Irritability.

ABSTRACT:

Objective

Childhood irritability, operationalized as disproportionate and frequent temper tantrums and low frustration tolerance relative to peers, is a transdiagnostic symptom across many pediatric disorders. Studies using task-dependent functional magnetic resonance imaging (fMRI) to probe neural dysfunction in irritability have increased. However, an integrated review summarizing the published methods and synthesized fMRI results remains lacking.

Method

We conducted a systematic search using irritability terms and task functional neuroimaging in key databases in March 2021, and identified 30 studies for our systematic review. Sample characteristics and fMRI methods were summarized. A subset of 28 studies met the criteria for extracting coordinate-based data for quantitati

SUBMITTER: Lee KS 

PROVIDER: S-EPMC9892288 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature