Organization, dynamics and mechanoregulation of integrin-mediated cell-ECM adhesions.

ABSTRACT: The ability of animal cells to sense, adhere to and remodel their local extracellular matrix (ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling, and hence to development, tissue formation, wound healing and the immune response. Cell-ECM interactions occur at various specialized, multi-protein adhesion complexes that serve to physically link the ECM to the cytoskeleton and the intracellular signalling apparatus. This occurs predominantly via clustered transmembrane receptors of the integrin family. Here we review how the interplay of mechanical forces, biochemical signalling and molecular self-organization determines the composition, organization, mechanosensitivity and dynamics of these adhesions. Progress in the identification of core multi-prote

SUBMITTER: Kanchanawong P 

PROVIDER: S-EPMC9892292 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature