Ontology highlight
ABSTRACT:
SUBMITTER: Oaks Z
PROVIDER: S-EPMC9892301 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Oaks Z Z Patel A A Huang N N Choudhary G G Winans T T Faludi T T Krakko D D Duarte M M Lewis J J Beckford M M Blair S S Kelly R R Landas S K SK Middleton F A FA Asara J M JM Chung S K SK Fernandez D R DR Banki K K Perl A A
Nature metabolism 20230119 1
Oxidative stress modulates carcinogenesis in the liver; however, direct evidence for metabolic control of oxidative stress during pathogenesis, particularly, of progression from cirrhosis to hepatocellular carcinoma (HCC), has been lacking. Deficiency of transaldolase (TAL), a rate-limiting enzyme of the non-oxidative branch of the pentose phosphate pathway (PPP), restricts growth and predisposes to cirrhosis and HCC in mice and humans. Here, we show that mitochondrial oxidative stress and progr ...[more]