HIV-1 reservoir evolution in infants infected with clade C from Mozambique.

ABSTRACT:

Background

The persistence of HIV-1-infected cells during antiretroviral therapy is well documented but may be modulated by early initiation of antiretroviral therapy in infants.

Methods

Here, we longitudinally analyzed the proviral landscape in nine infants with vertical HIV-1 infection from Mozambique over a median period of 24 months, using single-genome, near full-length, next-generation proviral sequencing.

Results

We observed a rapid decline in the frequency of intact proviruses, leading to a disproportional under-representation of intact HIV-1 sequences within the total number of HIV-1 DNA sequences after 12-24 months of therapy. In addition, proviral integration site profiling in one infant demonstrated clonal expansion of infected cells harboring intact provi

SUBMITTER: Koofhethile CK 

PROVIDER: S-EPMC9892347 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature