Acute effect of propranolol on resting energy expenditure in hyperthyroid patients.

ABSTRACT:

Objective

Hyperthyroidism is a common endocrine disorder which leads to higher resting energy expenditure (REE). Increased activity of brown adipose tissue (BAT) contributes to elevated REE in hyperthyroid patients. For rapid control of hyperthyroid symptoms, the non-selective β-blocker propranolol is widely used. While, long-term treatment with propranolol reduces REE it is currently unclear whether it can also acutely diminish REE.

Design

In the present prospective interventional trial we investigated the effect of propranolol on REE in hyperthyroid patients.

Methods

Nineteen patients with overt primary hyperthyroidism were recruited from the endocrine outpatient clinic. REE was measured by indirect calorimetry before and after an acute dose of 80mg propranolol and

SUBMITTER: Senn JR 

PROVIDER: S-EPMC9892445 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature