The protective effects of lipoxin A4 on type 2 diabetes mellitus: A Chinese prospective cohort study

ABSTRACT:

Background

Several cellular and animal studies have suggested that lipoxin A4 (LXA4) has a protective effect on type 2 diabetes mellitus (T2DM) development. However, little is known about whether LXA4 influences T2DM development at the population level.

Methods

We included 2755 non-diabetic participants from a cohort study in China who were followed for about seven years. Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for the association between LXA4 and incident T2DM. Mediation models were used to examine how serum lipids as mediators impact the association between LXA4 and T2DM.

Results

In total, 172 newly diagnosed T2DM cases were identified. Multivariate-adjusted HR for T2DM in the fourth compared wit

SUBMITTER: Wang S 

PROVIDER: S-EPMC9892446 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature