Effects of bilateral sequential theta-burst stimulation on 5-HT_1A receptors in the dorsolateral prefrontal cortex in treatment-resistant depression: a proof-of-concept trial.

ABSTRACT: Theta-burst stimulation (TBS) represents a brain stimulation technique effective for treatment-resistant depression (TRD) as underlined by meta-analyses. While the methodology undergoes constant refinement, bilateral stimulation of the dorsolateral prefrontal cortex (DLPFC) appears promising to restore left DLPFC hypoactivity and right hyperactivity found in depression. The post-synaptic inhibitory serotonin-1A (5-HT_1A) receptor, also occurring in the DLPFC, might be involved in this mechanism of action. To test this hypothesis, we performed PET-imaging using the tracer [carbonyl-¹¹C]WAY-100635 including arterial blood sampling before and after a three-week treatment with TBS in 11 TRD patients compared to sham stimulation (n = 8 and n = 3, respectively). Treatment gr

SUBMITTER: Murgas M 

PROVIDER: S-EPMC9892572 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature