Influence of storage and buffer composition on the mechanical behavior of flowing red blood cells.

ABSTRACT: On-chip study of blood flow has emerged as a powerful tool to assess the contribution of each component of blood to its overall function. Blood has indeed many functions, from gas and nutrient transport to immune response and thermal regulation. Red blood cells play a central role therein, in particular through their specific mechanical properties, which directly influence pressure regulation, oxygen perfusion, or platelet and white cell segregation toward endothelial walls. As the bloom of in-vitro studies has led to the apparition of various storage and sample preparation protocols, we address the question of the robustness of the results involving cell mechanical behavior against this diversity. The effects of three conservation media (EDTA, citrate, and glucose-albumin-sodium-phosphate

SUBMITTER: Merlo A 

PROVIDER: S-EPMC9892622 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature