Electrical, structural, and autonomic atrial remodeling underlies atrial fibrillation in inflammatory atrial cardiomyopathy.

ABSTRACT:

Background

There is growing evidence indicating a close relationship between inflammation and atrial fibrillation (AF). Although underlying inflammatory atrial cardiomyopathy may contribute to the development of AF, the arrhythmogenic remodeling caused by atrial inflammation has not been elucidated in detail. Herein, we examined electrical, structural, and autonomic changes in the atria in a mouse model of autoimmune myocarditis.

Methods

BALB/c mice were immunized with cardiac myosin peptide (MyHC-α_614-629) conjugated with complete Freund's adjuvant on days 0 and 7. Susceptibility to AF was assessed using right-atrial burst pacing.

Results

The mice immunized with MyHC-α_614-629 showed an inflammatory atrial cardiomyopathy phenotype, with enlarged

SUBMITTER: Murakata Y 

PROVIDER: S-EPMC9892626 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature