The association of alanine aminotransferase and diabetic microvascular complications: A Mendelian randomization study.

ABSTRACT:

Aims

Alanine aminotransferase (ALT) is positively related to diabetes risk in observational studies, whereas Mendelian randomization supports a linear causal association. In contrast, the relationship between ALT and diabetic nephropathy, and diabetic retinopathy is counter-intuitive in observational studies. Furthermore, no MR study has examined their causal association. The study aimed to investigate whether genetically determined ALT has a causal effect on diabetic nephropathy and diabetic retinopathy.

Methods

Genetic instruments associated with ALT (P < 5×10^-8) were obtained from a recent genome-wide association study (GWAS) that included 437,267 individuals of European ancestry. Summary data of diabetic microvascular complications were derived from the

SUBMITTER: Bi Y 

PROVIDER: S-EPMC9892708 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature