Prognostic factors in nonsmall cell lung cancer: insights from the German CRISP registry.

ABSTRACT:

Introduction

Understanding prognosis, especially long-term outcome, in advanced nonsmall cell lung cancer (NSCLC) is crucial to inform patients, guide treatment and plan supportive and palliative care.

Methods

Prognostic factors influencing overall survival (OS) and progression-free survival (PFS) in 2082 patients with wild-type (WT)-NSCLC (629 M1a, 249 M1b, 1204 M1c) are reported. Patients were included in the prospective German CRISP registry recruiting in >150 centres. Analysis for pre-therapeutic factors was based on results from Cox proportional hazard models.

Results

Current M-descriptors of the Union for International Cancer Control-8 staging system were validated: M1a and M1b patients had significantly longer median time to events compared to M1c (OS/PFS 16.4/

SUBMITTER: Metzenmacher M 

PROVIDER: S-EPMC9892864 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature