Initial statin dose after myocardial infarction and long-term cardiovascular outcomes.

ABSTRACT:

Aims

Effective statin therapy is a cornerstone of secondary prevention after myocardial infarction (MI). Real-life statin dosing is nevertheless suboptimal and largely determined early after MI. We studied long-term outcome impact of initial statin dose after MI.

Methods and results

Consecutive MI patients treated in Finland who used statins early after index event were retrospectively studied (N = 72 401; 67% men; mean age 68 years) using national registries. High-dose statin therapy was used by 26.3%, moderate dose by 69.2%, and low dose by 4.5%. Differences in baseline features, comorbidities, revascularisation, and usage of other evidence-based medications were adjusted for with multivariable regression. The primary outcome was major adverse cardiovascular or cerebrovasc

SUBMITTER: Kyto V 

PROVIDER: S-EPMC9892868 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature