The effect of Kuntai capsule on ovarian function in cisplatin-induced premature ovarian insufficiency rats.

ABSTRACT:

Objective

This study aims to evaluate the effect of Kuntai capsule on ovarian function in cisplatin-induced premature ovarian insufficiency rats and to explore the mechanism of Kuntai capsule on the ovarian function of rats.

Methods

Seventy-four female Sprague-Dawley rats were used for this study. Eight of the rats were randomly assigned to the Control group. The remaining sixty-six rats were utilized to establish the POI model via Cisplatin and then randomly divided into four groups: the model Control group, the Estradiol group, and groups treated with low and high doses of Kuntai capsule. For the 28-day administration, the Control and model Control groups were intragastrically administered with 2.0 mL of 0.9% sodium chloride daily, the Estradiol group with 2.0 mL of

SUBMITTER: Luo S 

PROVIDER: S-EPMC9892898 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature