Structural brain signatures of frailty, defined as accumulation of self-reported health deficits in older adults.

ABSTRACT:

Background

Frailty in older adults has been associated with reduced brain health. However, structural brain signatures of frailty remain understudied. Our aims were: (1) Explore associations between a frailty index (FI) and brain structure on magnetic resonance imaging (MRI). (2) Identify the most important FI features driving the associations.

Methods

We designed a cross-sectional observational study from a population-based study (The Irish Longitudinal Study on Aging: TILDA). Participants aged ≥50 years who underwent the wave 3 MRI sub-study were included. We measured cortex, basal ganglia, and each of the Desikan-Killiany regional volumes. Age-and sex-adjusted correlations were performed with a 32-item self-reported FI that included conditions commonly tested for frailty

SUBMITTER: Gutierrez-Zuniga R 

PROVIDER: S-EPMC9892944 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature