Physiological and transcriptome analysis of Candida albicans in response to X33 antimicrobial oligopeptide treatment.

ABSTRACT:

Introduction

Candida albicans is an opportunistic pathogenic fungus, which frequently causes systemic or local fungal infections in humans. The evolution of its drug-resistant mutants necessitate an urgent development of novel antimicrobial agents.

Results

Here, we explored the antimicrobial activity and inhibitory mechanisms of X33 antimicrobial oligopeptide (X33 AMOP) against C. albicans. The oxford cup test results showed that X33 AMOP had strong inhibitory activity against C. albicans, and its MIC and MFC were 0.625 g/L and 2.5 g/L, respectively. Moreover, SEM and TEM showed that X33 AMOP disrupted the integrity of cell membrane. The AKP, ROS, H₂O₂ and MDA contents increased, while the reducing sugar, soluble protein, and

SUBMITTER: Lu Q 

PROVIDER: S-EPMC9892945 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature