Anhedonia modulates benzodiazepine and opioid demand among persons in treatment for opioid use disorder.

ABSTRACT:

Background

Benzodiazepine (BZD) misuse is a significant public health problem, particularly in conjunction with opioid use, due to increased risks of overdose and death. One putative mechanism underlying BZD misuse is affective dysregulation, via exaggerated negative affect (e.g., anxiety, depression, stress-reactivity) and/or impaired positive affect (anhedonia). Similar to other misused substances, BZD consumption is sensitive to price and individual differences. Although purchase tasks and demand curve analysis can shed light on determinants of substance use, few studies have examined BZD demand, nor factors related to demand.

Methods

This ongoing study is examining simulated economic demand for alprazolam (among BZD lifetime misusers based on self-report and DSM-5

SUBMITTER: Greenwald MK 

PROVIDER: S-EPMC9892948 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature