Ontology highlight
ABSTRACT:
SUBMITTER: Tabernero J
PROVIDER: S-EPMC9892960 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Tabernero Josep J Bang Yung-Jue YJ Van Cutsem Eric E Fuchs Charles S CS Janjigian Yelena Yuriy YY Bhagia Pooja P Li Kan K Adelberg David D Qin Shu Kui SK
Future oncology (London, England) 20210512 22
Current guidelines recommend two-drug cytotoxic chemotherapy with a fluoropyrimidine (fluorouracil or capecitabine) and a platinum-based agent (oxaliplatin or cisplatin) as first-line treatment for advanced gastric cancer. Pembrolizumab monotherapy has demonstrated durable antitumor activity in patients with advanced programmed death ligand 1-positive (combined positive score ≥1) gastric/gastroesophageal junction adenocarcinoma. Accumulating evidence indicates that combining pembrolizumab with s ...[more]