Comparing blood biomarkers to clinical decision rules to select patients suspected of traumatic brain injury for head computed tomography.

ABSTRACT:

Introduction

Traumatic brain injury (TBI) is a major public health concern in the U.S. Recommendations for patients admitted in the emergency department (ED) to receive head computed tomography (CT) scan are currently guided by various clinical decision rules.

Objective

To compare how a blood biomarker approach compares with clinical decision rules in terms of predicting a positive head CT in adult patients suspected of TBI.

Methods

We retrospectively identified patients transported to our emergency department and underwent a noncontrast head CT due to suspicion of TBI and who had blood samples available. Published thresholds for serum and plasma glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolase-L1 (UCH-L1), and serum S100β were used to mak

SUBMITTER: Li Y 

PROVIDER: S-EPMC9893157 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature