Recruitment across two decades of NIH-funded Alzheimer's disease clinical trials.

ABSTRACT:

Background

Timely accrual of a representative sample is a key factor in whether Alzheimer's disease (AD) clinical trials successfully answer the scientific questions under study. Studies in other fields have observed that, over time, recruitment to trials has become increasingly reliant on larger numbers of sites, with declines in the average per-site recruitment rate. Here, we examined the trends in recruitment over a 20-year period of NIH-funded AD clinical trials conducted by the Alzheimer's Disease Cooperative Study (ADCS), a temporally consistent network of sites devoted to interventional research.

Methods

We performed retrospective analyses of eleven ADCS randomized clinical trials. To examine the recruitment planning, we calculated the expected number of participants

SUBMITTER: Ritchie M 

PROVIDER: S-EPMC9893207 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature