A Quantification Method for Disorganized Bone Components: Application to the Femoral Shaft.

ABSTRACT: Based on the current paradigm, a healthy bone is one with adequate mass without microarchitectural decay. However, these two features may not be sufficient to ensure that a bone is healthy. In addition, components must be correctly assembled and aligned. This ensures "the right amount of bone, at the right place" and thus, an optimal cohesion or interplay between constituents. Disorganization may be an independent contributor to bone abnormalities including fragility fractures. Indeed, many bone diseases may be characterized by the presence of disorganized bone, including osteogenesis imperfecta, hypophosphatasia, and atypical femur fractures (AFFs). Despite its likely importance, currently, there are no tools to quantify disorganization in vivo. We address this unmet need by descri

SUBMITTER: Zebaze R 

PROVIDER: S-EPMC9893270 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature