Clinical significance of neoadjuvant chemotherapy for locally advanced colorectal cancer patients with deficient mismatch repair: possibly residual value in the era of immunotherapy.

ABSTRACT:

Background

Deficient mismatch repair (dMMR) or microsatellite instability is one of the well-established molecular biomarkers in colorectal cancer (CRC). The efficiency of neoadjuvant chemotherapy (NAC) in locally advanced colorectal cancer (LACC) patients with dMMR is unclear.

Objectives

We assessed the tumor response and clinical outcome in LACC patients with dMMR received NAC.

Design

Retrospective, single-center analysis.

Methods

From 2013 to 2018, a total of 577 LACC patients with dMMR who underwent radical surgery were identified. Among them, 109 patients who received adjuvant chemotherapy were further screened out for analysis. According to whether receiving NAC or not, 109 patients were divided into two groups with the purpose of retrospectively analyzin

SUBMITTER: Chen M 

PROVIDER: S-EPMC9893354 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature