Elafin is related to immune infiltration and could predict the poor prognosis in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer (OC) is the most lethal gynecologic malignancy, yet the clinical results for OC patients are still variable. Therefore, we examined how elafin expression affects the patients' prognoses and immunotherapy responses in OC, which may facilitate treatment selection and improve prognosis.

Methods

The elafin mRNA expression profile was downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus. Elafin's prognostic potential and its relationship with clinical variables were investigated using Kaplan-Meier survival curves, time-dependent receiver operating characteristic curves as well as univariate and multivariate Cox regression models. As validation, protein expression in the tumor and adjacent tissues of OC patients was investigated by u

SUBMITTER: Lu W 

PROVIDER: S-EPMC9893492 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature