The association of BTLA gene polymorphisms with non-small lung cancer risk in smokers and never-smokers.

ABSTRACT:

Introduction

Lung cancer is the predominant cause of death among cancer patients and non-small cell lung cancer (NSCLC) is the most common type. Cigarette smoking is the prevailing risk factor for NSCLC, nevertheless, this cancer is also diagnosed in never-smokers. B and T lymphocyte attenuator (BTLA) belongs to immunological checkpoints which are key regulatory molecules of the immune response. A growing body of evidence highlights the important role of BTLA in cancer. In our previous studies, we showed a significant association between BTLA gene variants and susceptibility to chronic lymphoblastic leukemia and renal cell carcinoma in the Polish population. The present study aimed to analyze the impact of BTLA polymorphic variants on the susceptibility to NSCLC and N

SUBMITTER: Andrzejczak A 

PROVIDER: S-EPMC9893504 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature