Modulation of foraging-like behaviors by cholesterol-FGF19 axis.

ABSTRACT:

Background

Foraging for food precedes food consumption and is an important component of the overall metabolic programming that regulates feeding. Foraging is governed by central nervous system neuronal circuits but how it is influenced by diet and hormonal signals is still not well understood.

Results

In this study, we show that dietary cholesterol exerted suppressive effects on locomotor activity and that these effects were partially mediated by the neuropeptide Agouti-related protein (AgRP). High dietary cholesterol stimulated intestinal expression of fibroblast growth factor 15 (Fgf15), an ortholog of the human fibroblast growth factor 19 (FGF19). Intracerebroventricular infusion of FGF19 peptide reduced exploratory activity in the open field test paradigm. On the other h

SUBMITTER: Huang A 

PROVIDER: S-EPMC9893607 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature