PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models.

ABSTRACT:

Background

Cancer cells have developed molecular strategies to cope with evolutionary stressors in the dynamic tumor microenvironment. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α) is a metabolic rheostat that regulates diverse cellular adaptive behaviors, including growth and survival. However, the mechanistic role of PGC1α in regulating cancer cell viability under metabolic and genotoxic stress remains elusive.

Methods

We investigated the PGC1α-mediated survival mechanisms in metabolic stress (i.e., glucose deprivation-induced metabolic stress condition)-resistant cancer cells. We established glucose deprivation-induced metabolic stress-resistant cells (selected cells) from parental tumor cells and silenced or overexpressed PGC1α in selected and paren

SUBMITTER: Park KC 

PROVIDER: S-EPMC9893610 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature